A discovery about the way in which bugs spread throughout the body could help to develop stem cell treatments.
Researchers at the University of Edinburgh have found that bacteria are able to change the make-up of supporting cells within the nerve system, called Schwann cells, so that they take on the properties of stem cells.
Since stem cells can develop into any of the different cell types in the body mimicking this process could aid research into a range of degenerative conditions.
Scientists made the discovery studying bacteria that cause leprosy, which is an infectious neurodegenerative disease.
The study, carried out on mice, found that in the early stages of infection, the bacteria were able to protect themselves from the body's immune system by hiding in the Schwann cells.Once the infection was fully established, the bacteria were able to convert the Schwann cells to become like stem cells. Like typical stem cells, these cells could then become other cell types, for instance muscle cells.
This enabled the bacteria to spread to tissues in the body. The bacteria-generated stem cells can secrete specialised proteins - called chemokines - that attract immune cells, which in turn pick up the bacteria and spread the infection. Scientists believe these mechanisms, used by leprosy bacteria, could exist in other infectious diseases.
Knowledge of this newly discovered tactic used by bacteria to spread infection could help research to improve treatments and earlier diagnosis of infectious diseases.The study is published in the journal Cell.
Professor Anura Rambukkana, of the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh, who led the research, said: "Bacterial infections can completely change a cell's make up, which could have a wide-range of implications, including in stem cell research." The study, was funded by the US National Institutes of Health.
Fatal infection
It showed that when an infected Schwann cell was reprogrammed to become like a stem cell, it lost the function of Schwann cells to protect nerve cells, which transmit signals to the brain.
Professor Rambukkana added: "This is very intriguing as it is the first time that we have seen that functional adult tissue cells can be reprogrammed into stem cells by natural bacterial infection, which also does not carry the risk of creating tumorous cells.
"Potentially you could use the bacteria to change the flexibility of cells, turning them into stem cells and then use the standard antibiotics to kill the bacteria completely so that the cells could then be transplanted safely to tissue that has been damaged by degenerative disease," he added.
This discovery is important not just for our understanding and treatment of bacterial disease, but for the rapidly progressing field of regenerative medicine.
Researchers at the University of Edinburgh have found that bacteria are able to change the make-up of supporting cells within the nerve system, called Schwann cells, so that they take on the properties of stem cells.
Since stem cells can develop into any of the different cell types in the body mimicking this process could aid research into a range of degenerative conditions.
Scientists made the discovery studying bacteria that cause leprosy, which is an infectious neurodegenerative disease.
The study, carried out on mice, found that in the early stages of infection, the bacteria were able to protect themselves from the body's immune system by hiding in the Schwann cells.Once the infection was fully established, the bacteria were able to convert the Schwann cells to become like stem cells. Like typical stem cells, these cells could then become other cell types, for instance muscle cells.
This enabled the bacteria to spread to tissues in the body. The bacteria-generated stem cells can secrete specialised proteins - called chemokines - that attract immune cells, which in turn pick up the bacteria and spread the infection. Scientists believe these mechanisms, used by leprosy bacteria, could exist in other infectious diseases.
Knowledge of this newly discovered tactic used by bacteria to spread infection could help research to improve treatments and earlier diagnosis of infectious diseases.The study is published in the journal Cell.
Professor Anura Rambukkana, of the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh, who led the research, said: "Bacterial infections can completely change a cell's make up, which could have a wide-range of implications, including in stem cell research." The study, was funded by the US National Institutes of Health.
Fatal infection
It showed that when an infected Schwann cell was reprogrammed to become like a stem cell, it lost the function of Schwann cells to protect nerve cells, which transmit signals to the brain.
Professor Rambukkana added: "This is very intriguing as it is the first time that we have seen that functional adult tissue cells can be reprogrammed into stem cells by natural bacterial infection, which also does not carry the risk of creating tumorous cells.
"Potentially you could use the bacteria to change the flexibility of cells, turning them into stem cells and then use the standard antibiotics to kill the bacteria completely so that the cells could then be transplanted safely to tissue that has been damaged by degenerative disease," he added.
This discovery is important not just for our understanding and treatment of bacterial disease, but for the rapidly progressing field of regenerative medicine.